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This can occur as a result of: Leaky gut Crohns disease or ulcerative colitis Celiac disease and non-celiac gluten intolerance Small intestinal bacterial overgrowth (SIBO) Certain medications including: NSAIDS (ibuprofen), Antidepressants (Cymbalta, Effexor, Prozac, Zoloft), Antihistamines (Allegra, Benadryl ,Zyrtec), Histamine (H2) blockers (Pepcid, Zantac0, Immune modulators (Enbrel, Humira, Plaquenil), Antiarrhythmics/Calcium channel blockers (amlodipine, diltiazem, propanolol, metoprolol) DAO-blocking foods including alcohol can also lead to decreased availability of DAO to break down histamine, resulting in elevated levels

Tests in bacteria, cells, and mice all came back negative, suggesting the compound does not pose carcinogenic risk through DNA damage mechanisms

Tablets may be suitable for some people, particularly if their diet is low in B12 but their body can still absorb it properly

As well as producing red blood cells, vitamin B12 transports oxygen throughout the body