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In severe cases, alopecia areata can progress to alopecia totalis or alopecia universalis, resulting in hair loss across the entire body

Science 2009

54 The activation of NADPH oxidase is a dynamic process orchestrated by a cascade of kinase signaling, calcium release, and the activation of small GTPases, culminating in the subsequent activation of NOX2

Consistent with this notion, raft lipids are indeed enriched in recycling compartments and intermediates ( Perhaps because of the unique lipid composition of the lysosome, some of the clearest microscopic evidence for raft domains in living cells comes from studies of the vacuole in yeast, which is analogous to the mammalian lysosome