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SVs have been associated with pathogenic and biological mechanisms, including accessibility of genetic regulatory regions, expression efficiency, chromatin formation, and three-dimensional structure interactions, such as topological associating domains [3,4,5,6]

In the commonly studied horse liver isoform, Thr-48 is a Ser, and Leu-319 is a Phe

These pro-inflammatory mediators, along the lines of ROS, also stimulate -secretase activity and enhance the expression of amyloid precursor protein (APP), which promotes the processing of APP into the amyloid form (36)

In summary, the search for molecules that stably regulate autophagy mechanisms is a prerequisite for the development of autophagy-targeted drugs