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Bioinform 25 (5), bbae466

These cells contribute to the fibrotic response by activating resident fibroblasts and immune cells through the persistent induction of the TGF-/Smad, Wnt/-catenin, and Hedgehog signaling, which collectively drive myofibroblast differentiation and excessive extracellular matrix deposition

Modifications can be introduced into an antibody of the disclosure by standard techniques known in the art, such as site-directed mutagenesis and PCR-mediated mutagenesis