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Description

This decline may lead to symptoms such as fatigue, brain fog, dull skin, and poor sleep quality

For example, wild-type TP53 is able to inhibit glycolysis by suppressing the expression of GLUT1, GLUT3, and GLUT4 (160, 161), and regulating the expression of enzymes involved in the glycolytic pathway, such as HK2 (162), phosphofructokinase 1 (PFK1) (163), phosphoglycerate mutase (PGM) (163), pyruvate dehydrogenase (PDH), parkin 2 (PARK2) (164), and pyruvate dehydrogenase kinase (PDK2) (165)