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Although not yet clinically validated, adjunctive interventions including FMT, probiotics, and BA receptor agonists/antagonists warrant further investigation in the context of cellular therapy, particularly in metabolically dysregulated or immune-resistant tumors (152)

Interestingly, knockdown of Fasn , Scd1 , or the combination of both together with Srebf1 significantly decreased lipid accumulation in primary hepatocytes to a degree comparable to that observed upon GSH depletion (Figure 5N)

This enzymatic stimulation appears tissue-specific, as Epithalon selectively protected aged human pinealocytes from degenerative changes while promoting functional restoration of the gland's secretory capacity