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In addition to their cell defense function, local recruitment of NADPH oxidases, including non-phagocytic oxidases, has more recently been implicated in the production of ROS by growth factors and cytokines, though some of these may produce ROS by other means 24

Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, Motta L, Richardson A, Prolla TA

In addition, in HPV + head and neck cancer (HNC), E6 and E7 induce OS through NADPH oxidase (NOX) enzymes, leading to DNA damage, oxidative base lesions, and also DNA SSB chromosomal irregularities [51]

Verkerk AJ, Pieretti M, Sutcliffe JS, Fu Y-H, Kuhl DP, Pizzuti A, et al