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In support of this notion is our observation that sVLDLR, the soluble extracellular domain of VLDLR without the transmembrane and intracellular domains, can rescue the metabolic disturbance (Supplementary Fig

Both nutrients exert antidepressant effects through gut microbiota regulation, either by enhancing SCFA production or reducing inflammation, making them the most promising candidates for clinical translation (consistent with Sections 4.3, 5.3)