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doi: 10.3389/fendo.2019.00093 Received 15 October 2018 Accepted 01 February 2019 Published 01 March 2019 Volume 10 - 2019 Edited by Yang Yang, Northwest University, China Reviewed by Zhenxing Liang, First Affiliated Hospital of Zhengzhou University, China

The availability of cellular GSH is an important factor for MG detoxification via the glyoxalase system as the lack of GSH restricts hemithioacetal formation, resulting in MG accumulation ( Figure 1 )