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Although mouse and human XDH has some functional similarities, species differences in base/amino acid sequences and protein spatial conformation mean that innovative, highly selective small molecule inhibitors or small nucleic acid drugs designed against human XDH often face "acclimatization" issues in wild-type mice, resulting in significantly compromised binding affinity or efficacy

85 GPX2 is poorly expressed in healthy lungs, whereas GPX2 markedly increases in the airway epithelium in response to cigarette smoke exposure and inflammation

485 DOX can chelate Fe 3+ to form a complex with Fe 2+ , which triggers excessive lipid peroxidation within mitochondria, resulting in mitochondria-dependent ferroptosis

The peptide comes as lyophilized powder requiring reconstitution with bacteriostatic water before use