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This binding activates MPST, which produces hydrogen sulfide (HS) and pyruvate, boosting mitochondrial respiration

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The role of mitochondrial transcription factor B2 (TFB2M), another regulator of mitochondrial gene expression, was observed in mouse TFB2M-KO -cells which had impaired mitophagy via defects in autophagosome-lysosome fusion, and this was associated with mitochondrial dysfunction, and deficient insulin release (Nicholas et al., 2017)