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The hexanucleosomal arrays were condensed by intermittent addition of MgCl 2 to adjust the concentration to 0, 0.2, 0.4, 0.6, 0.9, 1.2, 1.6, 2.0, 2.5, 3.0, and 3.5 mM

however, in MDD characterized by chronic inflammation and oxidative stress their accumulation may shift toward a pro-oxidant profile that increases neuronal vulnerability and exacerbates neuroimmune dysregulation