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However, when excess free Fe 2+ is present in the cell, ferritin is recruited and solubilized by specific cargo receptor recognition, and the released excess Fe 2+ in turn increases the formation of hydroxyl radicals through the Fenton reaction, inducing reactive oxygen species (ROS) production and increased susceptibility to cellular ferroptosis ( FIGURE 1 Lipid peroxidation is an important factor driving ferroptosis

Each patient has unique body chemistry, age, and health which will affect the rate at which nutrients are absorbed into their system

In the process of neutralizing free radicals, antioxidants themselves become oxidized