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Investigating neuroprotective roles of Bacopa monnieri extracts: mechanistic insights and therapeutic implications

The aforementioned observations prompt the question of whether NF-B directly regulates EAAT3 expression at the transcriptional level

Our findings confirmed the observations of Dineshkumar et al

Future studies should be done prior to determining the translatability of the current work to cholangiopathies, including evaluation of NAC treatment in WT mice, evaluating NAC potential toxicity, along with further age time points of treatment and potentially optimization of NAC delivery to the EHBD