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Simultaneously, some cells undergo cell cycle arrest and become senescent owing to the inhibition of cyclin-dependent kinases mediated by p21 activation through the DDR pathway 11

53 LindsayE

The detection of infectious agents not acceptable in UW rodent SPF housing was performed in concert with similar standards at Charles River and the NIA aging rodent colony

Key areas of investigation include: Gastrointestinal : Demonstrated protection against NSAID-induced ulcers, inflammatory bowel disease models, and esophageal damage in multiple animal studies Musculoskeletal : Accelerated healing of transected Achilles tendons, quadriceps muscles, and medial collateral ligaments in rat models Neurological : Neuroprotective effects in models of traumatic brain injury, nerve crush injury, and dopaminergic system damage Organ protection : Hepatoprotective, cardioprotective, and nephroprotective effects demonstrated in various toxicity models The primary limitation is that all evidence comes from animal models