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The transition of parental cells to IDTCs/DTPs may require activation of key signaling pathways such as pan-PI3 K, Akt, mTOR, FGFR, IGF1R, or the downstream STK11, B2M, APC, mTOR, KEAP1and JAK1/2 that confer ICI tolerance

Chen et al., 1993)

Complications during pregnancy Nausea and vomiting Often called morning sickness, nausea and vomiting are common problems during the early stages of pregnancy, although they can happen at any time of the day