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It is seen across a range of peptides and pharmaceutical compounds that carry ionic or charged components, particularly when those compounds are injected into sensitive or low-fat tissue without adequate buffering

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Environ Sci Pollut Res 27:1834518354

Ultrasonication: Ultrasonication applies high-frequency sound waves to reduce the size of multilamellar vesicles (MLVs) into smaller unilamellar vesicles (SUVs)