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The gut microbiota, which comprises approximately 100150 times more genes than the human genome, is found in the human intestines and includes approximately 1000 species and 7000 types of bacteria, gram-positive or gram-negative Firmicutes (including the species Lactobacillus, Eubacterium and Clostridium), and gram-negative Bacteroidetes form the majority of the bacteria (containing Bacteroides and Prevotella ) (Flowers and Ellingrod, 2015

rather, it is a biomimetic signaling molecule that restores cellular function to a more youthful and functional state

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However, hydrogen abstraction from the phenolic ring is more challenging since the phenolic hydrogen atoms in curcumin are intramolecularly hydrogen-bonded to the adjacent methoxy groups