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When to Call a Doctor Call immediately or go to the nearest emergency room if you or someone youre with experiences: Severe, uncontrollable vomiting or diarrhea (dehydration becomes dangerous quickly) Chest pain or difficulty breathing Seizures or loss of consciousness Any thoughts of suicide or self-harm High fever that isnt coming down Symptoms that feel unmanageable and are escalating If youre pregnant and going through withdrawal, medical supervision is not optional its essential

Secondly, when homocysteine rises, it drives the MS reaction faster, which reduces 5mTHF

MaksimovaMYIvanovAVVirusEDNikiforovaKAOchtovaFRSuanovaETet alImpact of glutathione on acute ischemic stroke severity and outcome: possible role of aminothiols redox status

It certainly makes sense when you consider that vitamin B12 is stored in the liver at amounts that can sustain one's life for several years without any dietary or other sources, per ODS