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Description

10.1126/sciadv.abd6280 18 ChenL.HuN.WangC.ZhaoH

NCCN Clinical Practice Guidelines in Oncology

Owing to the severe adverse effects of TGF- inhibitors, Cu, often serving as a cofactor for metalloenzymes, can accelerate lung cancer progression, while Cu chelators can downregulate MMPs to reduce TGF- levels (Poursani et al., 2023)