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Furthermore, off- targeting during hdRNAi also has the potential to silence the plant genes (host gene silencing hairpin RNA: HGS-hpRNAi)

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Pharmacological inhibitors of IL-1/IL-1R1 signaling have been characterized [140] and could become a less expensive alternative to anti-IL-1 or anti-IL-1R1 antibodies for reducing vaccine reactogenicity and sequalae