Numerous preclinical studies have demonstrated that innovative design can significantly overcome the bottleneck of low EPR effect caused by dense matrix of pancreatic cancer, and improve the tumor enrichment and penetration efficiency of nanoparticles
Cimetidine, a competitive inhibitor of OCT2, is approved for peptic ulcers and prevents acute cold allodynia after oxaliplatin injection (Sprowl et al., 2013)
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doi: 10.1016/j.pbb.2013.08.013
