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Muscle-Specific Effects In skeletal muscle specifically, these signaling events promote muscle fiber hypertrophy (increased muscle cell size), activation and proliferation of satellite cells (muscle stem cells that can fuse with existing fibers or form new fibers), increased myofibrillar protein content and contractile capacity, and overall muscle mass accretion

Inhibition of transforming growth factor- signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice

CYP7A1 regulates the overall rate of BA synthesis, while sterol 12-hydroxylase regulates the cholic acid (CA) to chenodeoxycholic acid ratio in the BA pool

Preclinical investigations have explored how repeated GHSR agonism influences markers of bone mineral density and lean tissue in animal models of aging or metabolic challenge