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Whole plants except roots were collected at hourly intervals (0, 1, 3, 6, 24 h) and daily intervals (0, 1, 2, 3 days) in three biological replicates for RNA sequencing (Supplementary Fig

~200 in mice) and lipid metabolism pathways (e.g., bile acid synthesis) are different, rendering animal study results non-translatable to humans (8890)

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Histone Protein Expression The transcription and translation of histone proteins themselves are tightly regulated, because excess accumulation of histones results in genomic instability, DNA damage, chromosome aggregation or loss, and cell death