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(PubMed) Essen A, Santaolalla A, Garmo H, et al

Such differences could explain, in part the divergent and at times apparently contradictory findings with proteasome inhibitors

The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007