The broad spectrum of substrates means GST activity has been implicated as a determinant of efficacy for many drugs [2,3], with isoenzyme, GST P1-1 most commonly associated with both innate and acquired drug resistance during cancer chemotherapy [1,4,5], including 5-fluorouracil- and cisplatin-resistant gastric cancers [6] and doxorubicin-resistant prostate cancer [7], because of overexpression in drug-resistant cell lines [8,9]
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Selective histamine H3 receptor antagonists for treatment of cognitive deficiencies and other disorders of the central nervous system
Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) inhibitors
