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The combination of GPX4 inhibitors with immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis increases the proportion of CD8 + T cells, enhances their cytotoxic activity and induces ferroptosis, thereby promoting chemotherapy resistance [42]

Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid

This complex then selectively binds to complementary sequences on target mRNA molecules, resulting in either mRNA degradation or translational repression, thereby modulating gene expression at the post-transcriptional level (Liang et al., 2023)

Transcriptomics offers a high-level overview of gene expression and is useful for broadly characterizing cellular phenotypes, such as exhaustion (145)