2-vinylpyridine glutathione Sensitive enzymatic cycling assay for and glutathione disulfide content Poly(2-vinyl pyridine)

Medical conditions that may explain prolonged fatigue exclude a patient from the diagnosis of CFS, as do a number of psychiatric illnesses such as melancholic depression, bipolar disorder, psychotic disorders, eating disorders, or substance use disorder within two years of the onset of fatigue (Afari and Buchwald 2003)

Using unreliable supplements Cheap or unapproved glutathione products may contain poorly absorbed or harmful ingredients

This may be attributed to the dimeric structure which hinders enzyme access to active sites, showcasing significant resistance to enzymatic degradation 49,55

Disadvantages comprise higher risk of particle aggregation and toxicity