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Additionally, mitochondrial function was improved post- HSYCR treatment, indicated by increased mitochondrial membrane potential and decreased Ca2 + levels

After 6 ~ 8 h of infection, replaced with fresh medium, and continued to maintained in 5% CO 2 at 37 C for 48 h

8 BigagliE.CinciL.PaccosiS.ParentiA.DAmbrosioM.LuceriC

The high risk of metastasis in these patients may be associated with epithelial-mesenchymal transition (EMT), which is induced by several transcriptional factors such as Snail1, Smad2, and Twist1/2