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Hypothyroid symptoms include: Weight gain or weight loss resistance Constipation Dry skin Hair loss Cold hands and feet

Both studies were conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and US Food and Drug Administration/European Medicines Agency guidelines for studies in people with renal or hepatic impairment Consent to Participate/Publish All participants provided written, informed consent

Elevated estrogen and progesterone stimulate uterine smoothmuscle cells, while family history, AfricanAmerican ancestry, early menarche, and late menopause increase susceptibility

Korangath et al , 2015