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In addition to increasing the activity of MMPs, HIFs increase the production of chondrocyte glycolysis and the mitochondrial activity of chondrocytes under hypoxia, but ultimately leads to chondrocyte death (191)

It augmented the abundance of Proteobacteria and Bacteroidetes in a mouse model of diabetes at the phylum level, ameliorating diabetes-associated dysbiosis and metabolic disorders of the intestinal microbiota