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To view a copy of this license, visit About this article Cite this article Fustin, JM., Ye, S., Rakers, C

The study followed 52 participants who underwent intense aerobic exercise, a known trigger for elevated zonulin and exercise-induced leaky gut

These studies include GWAS association analyses and linkage studies in affected families

Our data show that in mice intestinal barrier function is impaired before the clinical onset of arthritis, while in humans serum markers associated with impaired intestinal barrier function are also increased before the onset of RA and associated with a higher risk to develop RA later on