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High plasma and tissue choline concentrations are common in diseases characterized by chronic low-grade inflammation, supporting the role of choline in modulating immune cell activation and tissue damage ( 3.3.1 Autoimmune and degenerative diseases For instance, in rheumatoid diseases, lipidomic studies in synovial fluid have reported altered phospholipid profiles with enrichment of choline-containing lipids, such as PC (186), which correlate with enhanced ChoK expression and activity

The trial group improved more than the control group with 37 grade 1 patients (34.6%), compared with 28 (25.5%) in the control group, and 22 cases (20.6%) of grade 3 patients in the trial group, compared with 34 cases (30.9%) in the control group

Of pathophysiological importance, circulating cholesterol is a major component of atherosclerotic plaques [64]