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Alopecia Universalis The most extreme type, Alopecia Universalis, leads to complete loss of hair on the entire body, including eyelashes and eyebrows

Here, under certain conditions (e.g., specific cellular systems and CYP activities) tert-butylation of DNA bases by NMtBu may only be moderate, reflected by slightly increased mean TIs in the comet assays, not necessarily leading to mutations

In addition, DNMTis can promote the expression of the cancer testis antigen, which can help host CTL to distinguish tumor cells from healthy cells (Gallagher et al., 2017)