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The authors demonstrated that the increased methylation levels of the DACH1 promoter region were associated with triple-negative and stage IV BRCA with distant metastasis, while no methylation was detected in normal adjacent tissues [140]

4 Future perspectives and outlook Despite the promising performance of MOF-based delivery systems across insecticidal, fungicidal, herbicidal, and plant growth regulator applications, their large-scale agricultural deployment is still constrained by several shared challenges related to sustainability, environmental safety, economic feasibility, and regulatory acceptance

YAP is activated after the initiation of EMT, therefore increasing cells vulnerability to ferroptosis [102]

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