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Our novel NNMT inhibitors display excellent physical chemical properties (e.g., membrane permeability), selectivity, and cellular inhibitory activity against NNMT, concomitantly enhancing the levels of the cofactors SAM and NAD + that independently regulate cellular energy metabolism and epigenetic modifications

Pathway-level interest: Used to investigate mechanisms involved in cellular energy balance and lipid handling in controlled models

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Although not a physiological substrate of CD38, NGD + conversion to cGDPR enables sensitive detection by HPLC owing to product accumulation in the supernatant