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Description

Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits

The optimal dosing sequence is 5-Amino-1MQ first (50100mg fasted), followed by MOTS-c 46 hours later (510mg), allowing NAD+ replenishment before increased mitochondrial demand

During the metabolism of certain metallodrugs, the metal ions in the drugs may compete for binding to the metal centers of enzymes or interfere with their normal functions, which can significantly impact the drugs efficacy and side effects (Meja et al., 2018)

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