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[] NRF2 consists of an subunit that binds DNA via E26 transformation-specific (ETS) domain recognition of the GGAA core motif (GGAA), along with four regulatory subunits (1, 2, 1, and 2)

doi: 10.1097/FPC.0b013e32832af5a3 55

Patients with other severe electrolyte imbalances (e.g., hyponatremia, hypercalcemia) should have their condition corrected before diuretics, like hydrochlorothiazide