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Strategies to improve the explainability of models include (1) adopting explainable AI techniques such as attention mechanisms, Layer-wise Relevance Propagation, SHAP (SHapley Additive exPlanations), or LIME (Local Interpretable Model-agnostic Explanations)

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Given the importance of Tregs and TAMs in tumor radioresistance [8], dysregulated IDO and TDO activation in glioma cells would increase the cancer cells radioresistance