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Acquired data was processed and analysed using MestReNova software

doi: 10.3389/fendo.2021.620920 295 DupuisMLContiFMaselliAPaganoMTRuggieriAAnticoliSet al

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This publication provides validated evidence that neurofilament proteins can serve as biomarkers to subclassify disease severity in patients with ALS and also as markers of phenoconversion in pre-symptomatic carriers of pathogenic mutations