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SHR: spontaneously hypertensive rats, Norm: normal rats, Supplementary Figure 2 The results of response permutation tests in the positive ionization mode (A) and negative ionization mode (B) , Supplementary Figure 3 The GSEA results revealing gene enrichment in PPAR signaling pathway (A) and fatty acid degradation (B) , Supplementary Figure 4 (A) Cell viability was measured by CCK8 reagents under different concentrations of Ang II in RAOECs

Semi-automated image analysis of DAPI-stained neutrophils was performed using Fiji software (v.2.14/1.54f), and calculated using MATLAB-based customer-written scripts gating (Supplementary Materials 1), as outlined in Extended Data Fig

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