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According to the recently reported results of a phase 2 trial in patients with gastrointestinal stromal tumors, linsitinib achieved no objective responses in these patients, although the rate of 9-month clinical benefit, progression-free survival, and overall survival at 9 months was 40%, 52% and 80%, respectively [162]

For the biotinylation an appropriate volume of 10 mM Sulfo-NHS- Biotin solution (Pierce Chemical Co., Rockford, IL) solution was incubated with 200 ml of each BALF for 30 minutes at room temperature with agitation

The therapy is targeted to a defined area because steam will travel only between cells until it encounters natural barriers within the prostate

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