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Normally, it is located in the cytoplasm in an inactive complex with its inhibitor, IB

This is because the symptoms vary widely and specific lab work needs to be done to assess your true levels

Table 18: Efficacy Results in Study JMCH Based upon prospectively defined criteria (modified Southwest Oncology Group methodology) the objective tumor response rate for pemetrexed plus cisplatin was greater than the objective tumor response rate for cisplatin alone