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The hypofunctionality of dopaminergic neurotransmission in the prefrontal cortex is thought to be partly responsible for schizophrenia

In human, TMAO is mainly derived from gut, where the gut microbiota converts dietary nutrients into TMA, which is absorbed into the bloodstream through the intestinal mucosa, and then transformed into TMAO by hepatic flavin monooxygenases (FMOs) in the liver (Zeisel and Warrier, 2017