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38,39 The basic principles for starting these oral therapies are to initiate therapy with low doses and titrate upward every 2 weeks based on response and tolerability with trials of 2 to 3 months, although full benefits may take up to 6 months

3,210 Multiple randomized controlled trials and meta-analyses have shown letrozole has a similar safety profile and is more effective than clomiphene citrate in women with PCOS

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Unlike the points above, which each relate to ways of increasing the chance of finding effects, a final issue is about whether stimuli adequately or accurately capture the putative emotional odour