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[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Hamad H., Olsen B.B

22 Photodynamic therapy is used to treat many skin diseases, including actinic keratosis, basal cell carcinoma, intraepithelial lesions of the vulva and anus, and genital warts

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These chemically non-reducible all-carbon bonds, typically introduced via ring-closing metathesis (RCM) or ring-closing alkyne metathesis (RCAM), serve as effective surrogates for labile disulfide bonds, enhancing both the structural stability and metabolic resilience of peptide therapeutics ( Triazole linkages, generated through Cu(I) or Ru(I)-catalyzed azide-alkyne click cycloaddition, offer remarkable metabolic stability and synthetic versatility (White et al., 2020