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Figure 3 shows the synergistic positive feedback loop between ferroptosis and necroptosis, where ROS released during Erastin-induced ferroptosis triggers necroptosis, which in turn releases more ROS and iron to amplify the overall cell death signal

Wang and colleagues explored the role of ovarian cancer cells microenvironment and showed that fibroblasts decreased the nuclear accumulation of platinum in cancer cells through glutathione and cysteine release

Repeated injections into the same subcutaneous site (abdomen, thigh) cause tissue induration (hardening) and reduce subsequent absorption efficiency

This phenomenon can lead to the transformation of inflammatory regions into pre-tumor microenvironments [60, 61]