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Stem cell source seems not to affect the incidence of infectous complications after allo-HSCT, but the number of patients were small in some subgroups

Melatonin can directly scavenge ROS through its electron-rich indole ring, and it can also induce antioxidant enzymes such as GPX, SOD, and catalase to achieve antioxidative effects

Also valine has been proven important for the oxidation of the reduced flavin by molecular oxygen in choline oxidase and it has been reported that replacement of Val464 with alanine in the enzyme results in a twofold decrease in the limiting rate constant for flavin reduction (k red ) and less than fivefold decrease in the equilibrium constant for formation of the enzymesubstrate complex (K d ) 52

This increases cyclic AMP, activates protein kinase A, and stimulates pulsatile GH transcription and release