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Sensory changes, deafness or other ear problems, difficulty achieving pain control, poor response to carbamazepine, history of any skin lesions or oral lesions that could lead to perineural spread, ophthalmic division only or bilateral as suggestive of benign or malignant lesions or multiple sclerosis, age of onset under 40 years, optic neuritis, family history of multiple sclerosis

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Data availability All data are available upon request from the authors and summary data will be made available via the UK Biobank ( Funding This work was supported by Health Data Research UK, an initiative funded by UK Research and Innovation, Department of Health and Social Care (England) and the devolved administrations and leading medical research charities

50ml100ml for IV admixture or compounding applications