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After a period of fasting, reduced glucose levels trigger the release of glucagon from cells in the islets, which primarily acts in the liver to boost glucose production by enhancing glycogen breakdown and gluconeogenesis ( de novo lipogenesis (DNL), in addition to those absorbed from the bloodstream, are subsequently used to sequentially esterify glycerol to form triacylglycerols in the liver

Doses around 2,000 mg per day showed the maximum benefit

10.1016/j.parkreldis.2016.11.011 197 YangD.ZhaoD.Ali ShahS

It is also worth noting that the KD can affect the lipid profile in an individualised way (often by lowering TG but sometimes by raising LDL-C), which may call for adjustment of statin dosage or type (especially in people with FH)